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العربيةCell Re DM (CellREDM) — What the Product Is, How It Differs from Re2O, and What to Know
Cell Re DM (CellREDM) is a human tissue product made by processing donated human skin tissue. The tissue bank is Hans Biomed, and domestic sales are handled by Mid Medical.
Table of contents for this page
What is Cell Re DM?
Cell Re DM is a product made by processing donated human skin tissue, and the government classifies it as human tissue.
The terms may sound unfamiliar at first, so we explain them step by step, starting with the structure of the skin.
The skin is made up of the epidermis (the outer layer of the skin) on the outside and the dermis (the inner layer of the skin) on the inside. The dermis is the layer involved in the thickness and elasticity of the skin.
The tissue bank (an institution that processes and stores human tissue) is Hans Biomed.
Cell Re DM is not a product approved as a medical device. It is human tissue made by processing donated human tissue, and it is managed through a tissue bank.
As for the form in which the product is supplied and how it is prepared and injected,
What is acellular allogeneic dermis (ADM)?
The name is long and may feel difficult, so we start by explaining what it means.
Acellular allogeneic dermis (ADM, human dermis with the cells removed) is a material made by removing the cells from donated human skin and leaving the extracellular matrix (ECM, the structural component inside the skin) of the dermis. Cell Re DM is a product in which this material is made into small particles and injected into the skin. The purpose is to supplement the structural components inside the skin.
In simple terms — The cells are removed from donated skin, leaving only the net-like component that supports the skin. Cell Re DM is a product intended to break that component into fine pieces and place it in the skin.
How do Cell Re DM and Re2O differ?
The names and the materials look alike, so it is natural to be confused.
The two products have the same classification. Both are human tissue products made by processing donated human skin tissue.
| Item | Cell Re DM | Re2O |
|---|---|---|
| Category | Human tissue | Human tissue |
| Tissue bank | Hans Biomed | L&C Bio |
As for the cases in which we use one or the other of the two products,
How does Cell Re DM differ from other skin boosters?
Its material and classification differ from medical device skin boosters such as Rejuran. Cell Re DM is human tissue made from donated human skin tissue, and Re2O is in the same classification.
This is not a matter of which is superior. They differ only in what they are made of and in the government's classification.
Putting what each is made of side by side makes the difference clear at a glance.
| Product | What is it made of? | Category |
|---|---|---|
| Cell Re DM | Dermis of donated human skin (acellular allogeneic dermis, ADM) | Human tissue |
| Re2O | Dermis of donated human skin (acellular allogeneic dermis, ADM) | Human tissue |
| Rejuran · Rejuran I · Rejuran HB Plus | Polynucleotide (PN, an ingredient made from DNA fragments) | Medical device |
What changes when something is classified as human tissue?
Medical devices used as skin boosters are approved product by product by the Ministry of Food and Drug Safety. So each product has its own approved intended use.
Because this is about regulation it may feel dry, but it is information you need to make an informed decision, so we explain it briefly.
Human tissue is not approved by reviewing the efficacy of each product the way medical devices are. Instead, the tissue bank that handles the tissue receives approval from the Ministry of Food and Drug Safety, and donor testing and the processing and storage procedures are managed under oversight.
Before the procedure, we explain that Cell Re DM is a product that comes from human tissue and obtain your consent.
We also keep a record of which tissue was used for whom.
Rejuran Procedure Information · Skin Booster Types and How to Choose
See more Cell Re DM product photos
For which concerns is Cell Re DM considered?
Cell Re DM is considered when the concern is the condition of the skin itself rather than hollowness or sagging.
If you feel your skin is not what it used to be, first tell us which change bothers you most.
At the consultation, we look at the type of concern before the product name. The suitable method differs depending on whether the problem is the skin itself, hollowness, or sagging. The criteria for telling them apart are summarized in How to Choose a Skin Booster.
Can it also be used under the eyes or on the neck?
Where to use it is decided after an examination.
If you are worried about thin-skinned areas such as under the eyes, we start by showing why it is done differently for each area.
How is Cell Re DM treatment carried out? Does it hurt?
At the consultation, your skin condition and the area are determined, and after anesthesia it is injected.
1. Consultation
We start by listening to what is bothering you and examine your skin condition. If we judge that another method suits you better than Cell Re DM, we will tell you so.
2. Explanation and Consent
We explain the treatment area and the reactions that can occur. We also explain separately that Cell Re DM is a product that comes from donated human tissue.
3. Anesthesia
The anesthesia method and the waiting time
4. Preparation
The product is prepared according to the instructions for use.
5. Injection
It is injected with a needle or a cannula (a tube with a rounded tip). The tool and depth vary by area.
6. Aftercare Instructions
We explain what to be careful of at home and the symptoms for which you should contact us.
How painful is Cell Re DM?
Pain varies by area. Thin-skinned areas such as under the eyes are more sensitive.
If you are worried about pain, please feel free to tell us at the consultation.
As for how long the procedure takes,
I hear Cell Re DM is donated human tissue, and I'm worried
Cell Re DM is a product made by a government-approved tissue bank that processes donated skin tissue. Even so, you should know that it comes from human tissue before you decide.
It is natural to feel concerned by the words "human tissue."
Human tissue as defined by law includes bone, cartilage, fascia, skin, amniotic membrane, ligaments, tendons, heart valves, and blood vessels, and skin is included. A tissue bank is an institution that has facilities and equipment and has received approval from the Minister of Food and Drug Safety. By law, tissue that is infected, or suspected of being infected, with a communicable disease such as hepatitis B or C, syphilis, or acquired immunodeficiency syndrome (AIDS) may not be distributed or transplanted.
The tissue bank that processed Cell Re DM is Hans Biomed.
Donor testing and processing and sterilization are procedures meant to reduce the risk of transmitting infection.
How are donor testing and processing done?
The Cell Re DM instructions for use state that the following items are checked in donor screening tests.
- Human immunodeficiency virus (HIV) antibody and nucleic acid amplification test (NAT)
- Hepatitis B (HBsAg, HBV NAT, anti-HBc)
- Hepatitis C (anti-HCV, NAT)
- Syphilis test
The raw tissue is collected in the United States, the Netherlands, Bulgaria, and South Korea.
The Cell Re DM instructions for use state, "In donor screening and processing, strict regulations are applied, so the risk of transmitting infectious agents is low, but a possibility may exist."
Before the procedure, we explain this and obtain your consent. Please feel free to ask at the consultation if you have further questions.
Frequently Asked Questions
What can you expect from Cell Re DM, and what is hard to expect?
What we expect from Cell Re DM is the supplementing of structural components inside the skin. We do not entrust Cell Re DM with lifting sagging areas or filling hollow areas.
This is something we want you to know before receiving it, so we make it clear first.
Cell Re DM is human tissue. Human tissue is not approved by reviewing the efficacy of each product the way medical devices are. For that reason, we do not promise the effects of Cell Re DM in numbers or in a time period.
The concerns below are difficult to expect to be addressed with Cell Re DM. We have also listed the pages with the appropriate information.
- Sagging cheeks and jawline: Lifting Selection Criteria, Thread Lift Procedure Information
- Drooping eyelids: Droopy Eyelid Surgery (Upper Blepharoplasty) Information
- When a lot of volume is needed because of marked hollowness: Filler Procedure Information
As for how we explain when you will notice a change and how long it lasts,
How many times and at what intervals is Cell Re DM given?
How many times and at what interval to receive Cell Re DM is decided at the consultation after looking at your skin condition.
How many visits you will need is essential information for planning your schedule, so it may be the first thing you wonder about.
| Item | Details |
|---|---|
| Number of sessions | |
| Interval |
If you have an event such as a gathering or a photo shoot, please tell us at the consultation. Redness or swelling may be present right after the procedure, so it is best to set the date with some time to spare before the event.
What side effects can Cell Re DM cause? When should I contact you?
Because it is placed by injection, bruising, swelling, lumps that can be felt, and allergic reactions can occur. Rarely, if the injected material enters a blood vessel, the skin can be damaged or vision problems can occur.
Reactions at the injection site
- Redness at the injection site
- Swelling
- Bruising
- Embossing (a raised bump at the injection site)
- Tenderness (pain when pressed)
Conditions that may require treatment
- Infection
- Hypersensitivity reaction (allergic reaction)
- Nodules (palpable lumps)
- Granuloma (an inflammatory lump that forms when the body recognizes something as a foreign substance)
- When the injected material enters a blood vessel
- Transmission of infection through donated tissue (very rare)
Do not wait in these cases
The changes below are ones you should tell us about without waiting until your next visit.
If something after the procedure feels wrong, do not endure it alone.
- When your vision suddenly becomes unclear or looks abnormal
- When the skin color of the treated area changes
- When the pain becomes severe
- When you have a fever
- When only one side becomes severely swollen or red
- When bruising or swelling does not decrease and gradually worsens
- When hives appear or itching is severe
- When a lump stays the same or grows after a week
- When a new lump can be felt after some time has passed, or the area becomes red and swollen
If your vision suddenly becomes unclear, do not wait, regardless of clinic hours, and go to the emergency room.
If you develop hives all over your body, are short of breath, or your lips or throat swell, call 119 or go to an emergency room.
A Word from the Doctor
"…The procedure itself is important, but sufficient follow-up care after the procedure is also important. In a way, you could say that what comes after surgery is even more important."
Precautions After Cell Re DM Treatment
- On the day of the treatment, it is best to avoid saunas, jjimjilbang (Korean bathhouses), strenuous exercise, and alcohol.
- If bruising appears, apply a cold compress for the first few days, and keep the area warm after that.
As for when you can wash your face and wear makeup,
Is Cell Re DM a filler?
No. Cell Re DM is a product whose packaging is labeled as human tissue. Filler is used to fill the volume of hollow areas. We do not use Cell Re DM for filling volume.
Which is better, Cell Re DM or Re2O?
We cannot say that either one is better. The two products fall into the same human tissue classification. The confirmed differences are the tissue bank and the packaging specifications. Cell Re DM is from Hans Biomed, and Re2O is from L&C Bio. Which one to consider is decided at the consultation after looking at your skin condition.
Is Cell Re DM the same as hyaluronic acid filler?
No. It is a human tissue product made by processing donated human skin tissue. For that reason, it is difficult to dissolve it with the drug that dissolves hyaluronic acid filler.
How long do the effects of Cell Re DM last?
We do not state a set period. Cell Re DM is human tissue, and human tissue is not approved by reviewing the efficacy of each product the way medical devices are. We explain this at the consultation after looking at your skin condition.
Can I have Cell Re DM together with surgery?
It depends on the type of surgery. In some cases it is done on the same day, and in others on separate days. The criteria are given in Can skin boosters and surgery be done together?
References
- Sclafani AP, Romo T 3rd, Jacono AA. Rejuvenation of the aging lip with an injectable acellular dermal graft (Cymetra). Arch Facial Plast Surg. 2002;4(4):252–257. PMID 12437432. doi:10.1001/archfaci.4.4.252.
- Beleznay K, Carruthers JDA, Humphrey S, Carruthers A, Jones D. Update on Avoiding and Treating Blindness From Fillers: A Recent Review of the World Literature. Aesthet Surg J. 2019;39(6):662–674. PMID 30805636. doi:10.1093/asj/sjz053.
- Apte RS, Solomon SD, Gehlbach P. Acute choroidal infarction following subcutaneous injection of micronized dermal matrix in the forehead region. Retina. 2003;23(4):552–554. PMID 12972773. doi:10.1097/00006982-200308000-00021.
- Greenwald MA, Kuehnert MJ, Fishman JA. Infectious disease transmission during organ and tissue transplantation. Emerg Infect Dis. 2012;18(8):e1. PMID 22840823. PMCID PMC3414044. doi:10.3201/eid1808.120277.
He personally consults on and performs facial aging treatments such as facelift, droopy eyelid surgery, and thread lift. The doctor personally sees you from consultation through recovery.
About the DoctorThe content of this page is general medical information provided in accordance with the Medical Service Act, and the effects and recovery time of surgeries and procedures may vary by individual. All surgeries and procedures can cause side effects, so please make your decision only after a thorough consultation with a plastic surgery specialist.